NAFLD is pathogenically associated with insulin resistance and thus affects a significant proportion of individuals with type 2 diabetes mellitus. These patients are at increased risk of progressing to cirrhosis and its complications, with obesity and insulin requirements increasing the risk of developing advanced liver disease. In addition, NAFLD exacerbates hepatic insulin resistance and may predispose to the development of diabetes and cardiovascular disease. NAFLD is generally asymptomatic and often associated with normal liver enzymes and thus may be under-recognized. Diagnosis requires confirmation by hepatic steatosis, which can generally be done by imaging studies. Staging of NAFLD requires a liver biopsy. A diagnosis of NAFLD should prompt attention to management of metabolic risk factors. Further studies are required to identify pharmacotherapeutic agents that alter the natural history of the disease as well as to identify patients who will benefit most from treatment.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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