Combination Therapy

Experience, such as in the UKPDS (61), has shown that over time, most patients require treatment with more than a single diabetes medication in order to maintain adequate glycemic control. This is especially true of the elderly with long-duration diabetes, who may require multiple oral medications and insulin. The combination of drugs that enhance insulin action (TZD, metformin) with drugs that promote insulin secretion (SU-, megltinides-, incretin-based treatment) is a popular and effective approach.

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