Calpain

The calpain-10 gene encodes for a cysteine protease reported to be responsible for the association of a region in chromosome 2 with diabetes (80,81). A recent meta-analysis indicates that several single-nucleotide polymorphisms (SNPs) are responsible for the association, each with only a modest effect with relative risks between 1.10 and 1.5 (82). Genetic variation in calpain-10 may affect sensitivity (83) or insulin secretion (84). It has also been shown to inhibit a protease involved in mitochondrial function, which might relate to mitochondrial dysfunction as is often observed in type 2 diabetes (85).

Was this article helpful?

0 0
Emergency Panic Remedies

Emergency Panic Remedies

Eliminate Your Panic And Anxiety Attacks Instantly With These Proven Techniques! There’s
 very
 little
 in
 this 
world
 that 
is
 as 
frightening
 and
 uncomfortable
 as 
a panic
 attack. 

Once
 they
 start,
 panic
 attacks
 can
 send
 you
 spiraling
 out
 of control.

Get My Free Ebook


Post a comment