Calcium Channel Blockers CCBs

Insulin release from pancreas depends on an increase in cytosolic calcium in vitro (34) and CCBs have been used in the treatment of insulinoma (35). It appears that induction of glucose intolerance by CCBs is dose-dependent and clinically used dosages do not pose any majorthreat, though few reports implicate therapeutic use of verapamil with marked hyperglycemia (36).

TABLE 2 Randomized Trials that Examined Incidence of New-Onset Diabetes

Trial

Primary treatment

Increase in new-onset diabetes by primary treatment

Comparator

Diabetes Sustenance

Diabetes Sustenance

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