Bb

Diuretic

0.57 (0.46-0.72) p < 0.0001 0.67 (0.56-0.80) p < 0.0001 0.75 (0.60-0.90) p = 0.002 0.77 (0.63-0.94) p = 0.009 0.90 (0.75-1.09) p = 0.30 Referent i

0.50 0.70 0.90 1.26 Odds ratio of incident diabetes Incoherence = 0.00017

FIGURE 8 Results of network meta-analysis of 22 clinical trials Abbreviations'. ACEi, angiotensin-converting-enzyme-inhibitor; ARB, angiotension Il-receptorablocker; BB, beta-blocker; CCB, calcium channel blocker. Source. From Ref. 103.

T2DM, decreasing the risk of diabetes represents a crucial treatment advantage beyond BP reduction, as new-onset diabetes increases vascular risk comparably to pre-existing diabetes and is associated with considerable morbidity and costs.

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