Maintenance Of Wholebody Glucose And Ffa Homeostasis

Glucose and FFA Homeostasis

In the postabsorptive (fasting) state, energy is derived primarily from the breakdown of endogenous fat stores, whereas hepatic, and, to a lesser extent, renal endogenous glucose production maintains blood glucose levels for utilization by organs such as the brain. Fatty acids derived from lipoprotein breakdown or released as FFAs from adipose tissue are oxidized as the main source of energy (Fig. 1 and Color Plate 2, following p. 34). Postprandially there is a shift toward storage of energy metabolites, mediated to a large extent by

A Post-absorptive/fasting period

B Postprandial period

Insulin-independent glucose uptake

Insulin-independent glucose uptake

Brain

Brain

Insulin action

f \ Fasting

Diabetes Sustenance

Diabetes Sustenance

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