For most of human evolution, the ability to store nutrients in the form of esterified lipids [triacylglycerols (TAG)] has constituted a survival advantage for times of famine and/or energy deficit. In more recent times, this "thrifty" fuel economy has been challenged by overconsumption of energy-dense foods and reduced physical activity, leading to dysfunction of major tissues and organs and alarming increases in the incidence of obesity-related diseases such as diabetes, hypertension, and cardiovascular disease. Skeletal muscle has received particular attention, because it is the major site of glucose disposal, accounting for approx 80% of glucose clearance in the postprandial state. With the recent advent and integration of tools of molecular biology and comprehensive

From: Contemporary Endocrinology: Type 2 Diabetes Mellitus: An Evidence-Based Approach to Practical Management Edited by: M. N. Feinglos and M. A. Bethel © Humana Press, Totowa, NJ

metabolic analysis, a review of mechanisms by which overconsumption of energy rich diets leads to insulin resistance in skeletal muscle seems warranted. Particular themes that will be highlighted in this chapter include: 1) Inter-organ communication networks among liver, adipose tissue, and muscle that contribute to muscle insulin resistance; 2) Critical evaluation of the idea that lipid-induced muscle insulin resistance occurs as a consequence of reduced fatty acid oxidation, leading to accumulation of toxic lipid-derived metabolites and TAG; 3) Discussion of an alternative and recently emergent concept that accumulation of lipid-derived metabolites that interfere with insulin action occurs due to an increase rather than a decrease in fatty acid oxidation in skeletal muscle.

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook

Post a comment