I

FFAs

(TRL and remnants)

Skeletal muscle

I TG stores, I FA oxidation I Glucose uptake and utilization

Fig. 3. Detrimental effects of chronic positive net energy balance. Overloading of adipose tissue beyond its storage capacity (energy intake exceeding energy expenditure) leads to lipid deposition in other tissues (skeletal muscle, pancreas, liver) via increased FFA flux and impaired FA oxidation. In turn, FFAs lead to altered insulin response/signaling, as illustrated for each of the major organs involved in energy homeostasis. Abbreviations are: FFA = free (nonesterified) fatty acid, FA = fatty acid, HGP = hepatic glucose production, LPL = lipoprotein lipase, TG = triglyceride, VLDL = very low density lipoprotein, TRL = triglyceride-rich lipoprotein (see Color Plate 4, following p. 34).

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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