What is the Pathophysiology of Elevated Plasma FFAs

Adipocyte Lipolysis And Circulatory Ffa

Plasma FFA concentration reflects a balance between release by the intravascular lipolysis of triglyceride-rich lipoproteins and lipolysis of predominantly adipose tissue triglyceride stores and tissue uptake predominantly re-esterified in adipose tissue and liver and oxidized in muscle, heart, and liver . In the postabsorptive state, the systemic FFA concentration is determined largely by the rate of FFA entry into the circulation, but postprandially the rate of uptake esterification,...

Insulin Hormone Sensitive Lipase Ketoacidosis

Insulin Tissue

I HGP Jglycogenolysis, I gluconeogenesis t Glucose uptake FA esterification I TG lipolysis t Glucose uptake FA esterification I TG lipolysis Fig. 1. Glucose and FFA homeostasis. A. Postabsorptive fasting period Stimulation of adipose tissue lipases, HSL and ATGL, by low plasma insulin concentrations and elevated glucagon, facilitates mobilization of stored triglycerides, releasing fatty acids into the circulation. Low insulin and high glucagon also stimulates gluconeogenesis from FFA and other...