The Modern

Banting's epochal discovery of insulin in 1921 changed not only the world of diabetes, but also the history of medicine (24). The postinsulin era brought a surge of research activities related to diabetic neuropathies. Several authors, including Jordan and Broch, observed a common dissociation between neuropathic symptoms and objective signs of disease (25,26). Wayne Rundles from the University of Michigan published a review of 125 cases of diabetic neuropathy. His observations created a basis for the suggestion that development of neuropathy is dependent on the degree of glycemic control (27). The work of Rundles, along with that of Root, significantly contributed to the understanding of diabetic autonomic neuropathy (28). Garland provided a description of the predominantly proximal, often transient, painful neuropathy not accompanied by sensory disturbances. He named the condition diabetic amyotrophy (29,30). Stainess and Downie, in the early sixties, started using quantitative sensory testing and nerve conduction studies in neuropathy research (31,32).

In 1959, Sven-Erik Fagerberg from Goteborg, on thoroughly studying 356 cases of diabetes, proposed an association among diabetic neuropathy, retinopathy, and nephropathy. In approx 50% of the cases, he performed microscopic analysis of peripheral nerves and discovered substantial abnormalities in the nerve microvasculature, especially prominent in those with clinical signs of neuropathy. By combining epidemiological and pathological evidence, Fagerberg proposed the theory that diabetic neuropathy, retinopathy, and nephropathy share an underlying microvascular pathology (33). In the arena of diabetic neuropathies, the end of the 20th century will be remembered as the period of large clinical trials testing potential therapeutic agents. So far none of the agents tested, with the exception of insulin, have as both safe and capable of altering the course of diabetic neuropathy (34). Therefore, the race continues.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

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