Diabetic foot complications are the result of an interplay between impaired wound healing, peripheral vascular disease and neuropathy. The peripheral neuropathy seen with diabetes mellitus affects sensory, motor and autonomic neurons and results in increased susceptibility to pathology. The most common problem is the presence of wounds that are difficult to heal. Therefore, the prevention of the formation of these wounds is of paramount importance in patients who are identified as being at risk for forming these wounds. Treatment involves a multidisciplinary approach and requires adequate perfusion, proper wound care, and appropriate protection of the wound from pressure or offloading. Neuroosteoarthropathy or Charcot's disease of the foot is also common in diabetic neuropathic patients. The main underlying cause is neuropathy which often results in the muscu-loskeletal disruption of the architecture of the foot and leads to severe deformity. Management of this condition is a challenge and failure may result in limb loss. The present chapter will review the pathophysiology of diabetic foot problems and the currently established therapeutic approaches.

Key Words: Foot complications; neuropathic ulcerations; charcot wounds.

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