Pathophysiology of neuropathic pain in diabetic neuropathy, also called painful diabetic neuropathy (PDN) is not well understood. Neither basic science nor clinical research provides clear insights into the pathophysiology of PDN. Pathology of the PDN has been predominantly studied at the level of the peripheral nervous system and consequently, all of PDN pathophysiological mechanisms are ascribed to the peripheral nervous system. However, it has been postulated that in addition to peripheral mechanisms, central nervous system mechanisms probably play significant role in the overall manifestations of the PDN (1). Diabetes has effects on many aspects of brain function that are probably subtle, but significant (2-7). These include effects on mood (2,4), which are known to influence modulation of pain perception (8) and as such would have effect on perception of pain in case of PDN; however, no study has investigated those

From: Contemporary Diabetes: Diabetic Neuropathy: Clinical Management, Second Edition Edited by: A. Veves and R. Malik © Humana Press Inc., Totowa, NJ

aspects of diabetes. Consequently, this chapter reviews what is known about neuropathic pain in general, with the hope that this information can provide insight into PDN.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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