Genetic Factors And Diabetic Neuropathy

Over the past few years considerable data have emerged showing that genetic factors make an important contribution to the pathogenesis of diabetic microvascular complications (15). This explains why certain patients with good glucose control still develop diabetic microvascular complications, whereas, there are those with poor control who appear to escape the long-term complications of diabetes. The United Kingdom Prospective Diabetes Study showed that strict glycemic control can modify the risk of microvascular disease in patients with type 2 diabetes mellitus (T2DM). Previously, the Diabetes Control of Complications Trial (DCCT) in patients with type 1 diabetes mellitus (T1DM) showed that strict glycemic control can both delay the onset of microvascular complications and slow the rate of progression of already established complications. The DCCT was able to demonstrate a nonlinear relationship between the life-time risk of complications and mean levels of HbAlc (16,17).

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