D

Debridement, foot ulcer management, 487-489 Dementia, see Diabetic encephalopathy Dermagraft, foot ulcer management, 492, 493 Diabetic encephalopathy animal studies behavioral findings, 188 hippocampal synaptic plasticity, 188, 189 neurophysiological changes, 189 overview, 187, 188 pathogenetic mechanisms, 189, 190 structural abnormalities, 189 cognition studies clinical management, 198, 199 type 1 diabetes adults, 191 children, 190, 191 type 2 diabetes, 191-193 dementia studies, 193, 194 depression association, 193, 194 magnetic resonance imaging findings,

194, 196 neuropathological findings, 195 neurophysiology event-related potentials, 197 evoked potentials, 196, 197 therapeutic interventions, 197, 198 Diabetic foot, see Charcot neuroarthropathy;

Foot ulcer Diabetic neuropathy animal models, see BB/Wor rat;

BBZDR/Wor rat; Streptozotocin-induced diabetes clinical classification, 245, 246 clinical trial design confounding factors, 288 end points, 287, 288, 309, 310, 322, 323 painful neuropathy, 356 population selection, 287 study duration, 288 definition, 351

diagnosis, see Diagnosis, diabetic neuropathy epidemiology, see Epidemiology, diabetic neuropathy genetics, see Genetics, diabetic neuropathy historical perspective see, Historical perspective, diabetic neuropathy types, 8

Diagnosis, diabetic neuropathy axon reflex, 284

cardiovascular autonomic neuropathy,

390-394 composite scores, 283 corneal confocal microscopy, 285 differential diagnosis, 244, 245, 376 disability assessment, 277-279 electrophysiology action potentials, 282 F-wave, 282

nerve conduction velocity, 280-282 magnetic resonance imaging, 285 nerve biopsy, 284

quantitative sensory testing, 279, 280 skin biopsy, see Skin biopsy symptoms, 276, 277

ulceration risk assessment, 279, 280, 285-287 Diarrhea clinical findings and evaluation, 443, 444 management, 444, 445 pathogenesis in diabetes, 442, 443 Distal symmetrical neuropathy natural history, 249 overview, 246 signs, 246, 247 small fiber neuropathy, 248 symptoms, 246 Domperidone, gastroparesis management in diabetes, 441 Dorsal root ganglia (DRG)

apoptosis in diabetic neuropathy, 118, 119,

121-123 blood flow, 208-210 diabetes effects, 118 DRG, see Dorsal root ganglia Duloxetine, painful neuropathy management, 360 Dyslipidemia, diabetic neuropathy pathogenesis, 235, 236

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