Induction of PCD might also occur independently of Mt depolarization (47) by primarily cytosolic mechanisms. One key component of the cell death machinery, Apaf-1, in the presence of dATP forms a complex with cytochrome-c and caspase-9 (the apoptosome) (13,48,49). Selective binding of caspase-9 to Apaf-1 results in caspase-9-dependent hierarchical activation of caspases-2, -3, -6, -7, -8, and -10, resulting ultimately in DNA fragmentation seen in apoptosis (50-53). In turn, caspase-3 activates caspase-2, -6, -8, and -10 and amplifies caspase-9 cleavage (50). In contrast, BCL-2 and BCL-xL complex with Apaf-1 and caspase-9 through different binding sites to form a ternary complex (48) that inhibits cleavage of downstream caspases (48) and serve to inhibit PCD.
Was this article helpful?
All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.