Contents

Preface vii

List of Color Images viii

Contributors xi

1 Historical Aspects of Diabetic Neuropathies 1

Vladimir Skljarevski

2 The Epidemiology of Diabetic Neuropathy 7

Stephanie Wheeler, Nalini Singh, and Edward J. Boyko

3 Genomics of Diabetic Neuropathy 31

Andrew G. Demaine and Bingmei Yang

4 Transgenic and Gene Knockout Analysis of Diabetic Neuropathy 51

Sookja K. Chung and Stephen S. M. Chung

5 Hyperglycemia-Initiated Mechanisms in Diabetic Neuropathy 69 Irina G. Obrosova

6 Effectors—Sonic Hedgehog and p38 Mitogen-Activated

Protein Kinase 91

Sally A. Price, Rebecca C. Burnand, and David R. Tomlinson

7 Neuronal and Schwann Cell Death in Diabetic Neuropathy 113

James W. Russell, Rita M. Cowell, and Eva L. Feldman

8 Metabolic-Functional-Structural Correlations in Somatic Neuropathies in the Spontaneously Type 1

and Type 2 Diabetic BB-Rats 133

Anders A. F. Sima, Weixian Zhang, and Hideki Kamiya

9 Experimental Diabetic Autonomic Neuropathy 153

Phillip A. Low

10 Spinal Cord: Structure and Function in Diabetes 165

Andrew P. Mizisin, Corinne G. Jolivalt, and Nigel A. Calcutt

11 Diabetic Encephalopathy 187

Geert Jan Biessels

12 Microangiopathy, Diabetes, and the Peripheral Nervous System 207

Douglas W. Zochodne

13 Pathogenesis of Human Diabetic Neuropathy 231

Rayaz Ahmed Malik and Aristides Veves

14 Clinical Features of Diabetic Polyneuropathy 243

Solomon Tesfaye x Contents

15 Micro- and Macrovascular Disease in Diabetic Neuropathy 259

Aristidis Veves and Antonella Caselli

16 Clinical Diagnosis of Diabetic Neuropathy 275

Vladimir Skljarevski and Rayaz A. Malik

17 Punch Skin Biopsy in Diabetic Neuropathy 293

Michael Polydefkis

18 Aldose Reductase Inhibitors for the Treatment of Diabetic Neuropathy 309

Aristidis Veves

19 Other Therapeutic Agents for the Treatment of Diabetic Neuropathy 321

Gary L. Pittenger, Henri Pharson, Jagdeesh Ullal, and Aaron I. Vinik

20 Pathophysiology of Neuropathic Pain 339

Misha-Miroslav Backonja

21 Treatment of Painful Diabetic Neuropathy 351

Andrew J. M. Boulton

22 Focal and Multifocal Diabetic Neuropathy 367

GĂ©rard Said

23 Hypoglycemia and the Autonomic Nervous System 379

Roy Freeman

24 Cardiovascular Autonomic Neuropathy 389

Martin J. Stevens

25 Postural Hypotension and Anhidrosis 413

Phillip A. Low

26 Gastrointestinal Syndromes Due to Diabetes Mellitus 433

Juan-R. Malagelada

27 Genitourinary Complications 453

Dan Ziegler and Christian Stief

28 Management of Diabetic Foot Complications 473

Thomas E. Lyons

Index 507

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