Multiple mechanisms are involved in the pathogenesis of PDN. New findings support the role for previously discovered mechanisms, such as increased AR activity, nonen-zymatic glycation, PKC activation, and oxidative stress in functional and morphological abnormalities in the diabetic nerve. Evidence for the important role for nitrosative stress, MAPK activation, PARP activation, COX-2 activation, and Ca2+ signaling is emerging. Several newly discovered mechanisms include activations of NF-kB, the 12/15-LO pathway, and NHE-1. Studies of the role for these mechanisms in PDN and their interactions with other pathogenetic factors are in progress.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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