Changes in the micro- and macrocirculation, both anatomical and functional, contribute to the development of diabetic neuropathy. On the other hand, the development of diabetic neuropathy also affects the vasodilatory capacity of the microcirculation and can interfere with the clinical presentation of peripheral obstructive arterial disease. Thus, the interaction between changes in the vasculature and peripheral nerves is bidirectional and results in changes in both blood flow and neuronal function.
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