It is clear from these data that the neuropathies occurring in the two BB-rat models show distinct differences in underlying metabolic and molecular changes, progression of functional deficits and the spectra of morphological changes despite the same exposure to hyperglycemia. Therefore the differences imply that hyperglycemia is only one component of the pathogenetic web underlying DPN. The other major component contributing to DPN is provided by the deficiencies in insulin and synergistically acting C-peptide, resulting in impaired insulin signaling. These latter defects appear to substantially add to the severity of the neural Na+/K+-ATPase defect and to be the major culprit in the perturbations of impaired neurotrophic support, and to be the sole factor in the development of nodal/paranodal dysfunction and pathology. Hence, these differences in underlying mechanisms explain the differences in the progression and severity between type 1 and type 2 DPN. Only by recognizing such differences in underlying factors and their associated dynamic consequences in the development of DPN will it be possible to approach these disorders therapeutically in biologically meaningful ways, as already documented by several successful C-peptide trials in type 1 DPN.

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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