Clinical Trials With Aris

Alrestatin

Alrestatin was the first ARI to be tried in human diabetic neuropathy. In the first, uncontrolled study conducted in 1981, 10 patients with symptomatic neuropathy were treated with intravenous infusions of alrestatin for 5 days (5). Although, symptomatic improvement was noticed in seven patients, objective measurements failed to improve. Therefore, as the trial was not controlled, a placebo effect accounting for the symptomatic improvement cannot be excluded. No adverse effects of alrestatin were noticed in this trial (Table 1).

The next trial included nine patients with diabetes with severe symptomatic neuropathy, which had necessitated at least one hospital admission before the study (6). The trial was a single-blind, nonrandomized, placebo-crossover, which lasted for 4 months. Each patient received the maximum tolerated oral dose for 2 months and was on placebo for the other two. Subjective improvement was noted by most of the patients

Table 1

ARIs Trials in Human Neuropathy

Duration of

Table 1

ARIs Trials in Human Neuropathy

Duration of

Authors

Design

active treatment

Results

Alrestatin

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment