Caspases And

The name caspase is derived from the specificity of these cysteine proteases to cleave their substrates after an aspartic acid. All caspases are synthesized as inactive zymogens called procaspases. At the onset of apoptosis, caspases undergo intramolecular cleavage and often this is followed by a second cleavage to remove the prodomain from the protease domain. The caspases form two primary groups, initiator caspases that include caspase-2, -8, -9, and -10, and effector caspases. Initiator caspases are the proximal death-inducing caspases that are activated in response to apoptotic stimuli; their primary function is to activate downstream effector caspases by catalyzing a single proteolytic cleavage. Activation of an effector caspase zymogen involves a specific intrachain cleavage, which is mediated by a specific initiator caspase. As a consequence of the intrachain cleavage, the catalytic activity of the effector caspase is enhanced by several orders of magnitude, thus magnifying the cell death inducing effect. Classically, PCD is induced by either extrinsic or intrinsic pathways.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook


Post a comment