Therapeutic Potential Of Hgf In Diabetic Nephropathy

Given that a loss in endogenous HGF production by hyperglycemia may be causative for the histological and clinical manifestations of diabetic renal disease, administration of exogenous HGF (or its gene) would inhibit or reverse the progression of diabetic renal injury. Using a model of DN, we obtained evidence that HGF may be a therapeutic factor for inhibiting TGF-P upregulation and renal fibrosis. We will discuss herein the relationship among molecular, histological, and clinical changes to understand the therapeutic effect of HGF in DN.

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