Contents

Dedication v

Series Editor's Introduction vii

Preface ix

Contributors xv

Part I: Basic Pathophysiology and Biochemistry of Diabetic Nephropathy

A. Pathophysiology

1. Angiotensin II and Its Receptors in the Pathogenesis of Diabetic Nephropathy 3

David J. Leehey, Ashok K. Singh, and Rekha Singh

2. Altered Renal Microvascular Function in Early Diabetes 23

Pamela K. Carmines, Joseph P. Bast, and Naohito Ishii

B. Interstitial Disease

3. Proteinuria and Interstitial Fibrogenesis in Diabetic Nephropathy 39

Raimund Hirschberg

C. Podocytes

4. Podocytes and Diabetic Nephropathy 59

George Jerums, Sianna Panagiotopoulos, and Richard MacIsaac,

D. Altered Metabolic Pathways

5. Altered Glucose Transport and Its Metabolic Effects in Glomerular Cells 81

Charles W. Heilig

6. mRNA Translation in Diabetic Nephropathy 97

Balakuntalam S. Kasinath, Myung Ja Lee,

Denis Feliers, and Nahum Sonenberg

7. The Hexosamine Biosynthesis Pathway:

Contribution to the Pathogenesis of Diabetic Nephropathy... 117 I. George Fantus, Howard J. Goldberg, Catharine I. Whiteside, and Delilah Topic

E. Nonenzymatic Glycosylation

8. Glycation: Receptor for Advanced Glycation

Endproducts and Diabetic Nephropathy 137

Vivette D'Agati and Ann Marie Schmidt

F. Oxidative Stress

9. Oxidative and Glycooxidative Stress in Diabetic Nephropathy 151

Frederick R. DeRubertis and Patricia A. Craven

G. Growth Factors

10. Connective Tissue Growth Factor in the Pathogenesis of Diabetic Nephropathy:

A Target for Therapeutic Intervention 175

Bruce L. Riser, Alessia Fornoni, and Sujatha Karoor

11. Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathy 187

Geoffrey Boner and Mark E. Cooper

12. Transforming Growth Factor-^ Signal Transduction in the Pathogenesis of Diabetic Nephropathy:

Identifying Molecular Targets for Therapeutic Intervention 201

Sheldon Chen and Fuad N. Ziyadeh

H. New Approaches to the Study of Diabetic Nephropathy

13. Hepatocyte Growth Factor: Physiological and Therapeutic

Ligand to Attenuate Diabetic Nephropathy 225

Shinya Mizuno and Toshikazu Nakamura

14. Proteomics in the Investigation of Diabetic Nephropathy 255

Visith Thongboonkerd

15. Gene Expression Profiling in the Investigation of Diabetic Nephropathy 277

Katalin Susztak, Erwin Bottinger, and Kumar Sharma

16. PPAR-y Ligands and Diabetic Nephropathy 289

Keiji Isshiki, Daisuke Koya, and Masakazu Haneda

17. a-Endosulfine in Diabetic Nephropathy 305

Jerry Yee and Balazs Szamosfalvi

18. The Prospect of a Novel Therapeutic, Bone Morphogenetic

Protein-7, in Diabetic Nephropathy 315

Keith A. Hruska, Laura DePetris, Tingting Li,

Song Wang, Theresa Geurs, Frank Strebeck,

Qing Chen, and Helen Liapis

Part II: Clinical Aspects of Diabetic Nephropathy A. Genetics and Risks

19. Genetic Determinants of Diabetic Nephropathy in Type 2 Diabetes 329

Grzegorz Placha and Andrzej S. Krolewski

20. Major Risk Indicators for Diabetic Kidney Disease 351

Katherine R. Tuttle

B. Histopathology and Special Populations

21. The Structure of Human Diabetic Nephropathy 361

Michael Mauer and Behzad Najafian

22. Diabetic Kidney Disease in Transitional and Disadvantaged Populations 375

E. Jennifer Weil and Robert G. Nelson

C. Diagnosis and Treatment

23. Screening and Treatment of Early Diabetic Renal Disease in Type 1 and Type 2 Diabetes 403

Ellie Chuang and Mark E. Molitch

24. Treatment in Advanced Renal Disease in Type 1

and Type 2 Diabetes 419

Eberhard Ritz and Gunter Wolf

25. Diabetic and Renal Disease:

ACE Inhibitors and/or Angiotensin Receptor Blockers:

Does It Matter? 437

Carl Erik Mogensen and Niels Holmark Andersen

26. Management of Diabetic End-Stage Renal Disease

With Dialysis 453

Ploumis S. Passadakis and Dimitrios G. Oreopoulos

D. Related Abnormalities

27. Diabetic Retinopathy and Nephropathy 473

Ronald Klein

28. Hypertension and Cardiovascular Disease 499

Adam Whaley-Connell, Kurt Sowers, and James R. Sowers

29. Endothelial Dysfunction and Diabetic Nephropathy 515

Alfons J. H. M. Houben, and Nicolaas C. Schaper

30. Anemia and Diabetic Nephropathy 527

George Jerums, Richard MacIsaac,

Sianna Panagiotopoulos, and Merlin Thomas

Index 549

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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