Iv

Staphylococcus aureus

Flucloxacillin 500 mg qds Sodium fusidate 500 mg tds Clindamycin 300 mg tds Rifampicin 300 mg tds

Flucloxacillin 500 mg qds Gentamicin 5 mg/kg/day

(according to levels) Clindamycin 150-600 mg qds

Methicillin-resistant Staphylococcus aureus (MRSA)

Sodium fusidate 500 mg tds Trimethoprim 200 mg bd Rifampicin 300 mg tds Doxycycline 100 mg daily Linezolid 600 mg bd

Vancomycin 1 gbd

(according to levels) Teicoplanin 400 mg daily

Linezolid 600 mg bd

Streptococcus

Amoxicillin 500 mg tds Flucloxacillin 500 mg qds Clindamycin 300 mg tds Erythromycin 500 mg qds

Amoxicillin 500 mgtds Clindamycin 150-600 mgqds

Enterococcus

Amoxicillin 500 mg tds

Amoxicillin 500 mg tds Vancomycin 1 gbd (according to levels)

Anaerobes

Metronidazole 400 mgtds Clindamycin 300 mg tds

Metronidazole 500 mg tds Clindamycin 150-600 mgqds

Coliforms (E. coli, Proteus, Klebsiella, Enterobacter)

Ciprofloxacin 500 mg bd Cefadroxil 1 gbd Trimethoprim 200 mg bd

Ciprofloxacin 200 mgbd

Ceftazidime 1-2 g tds

Ceftriaxone 1-2 g daily

Gentamicin 5 mg/kg/day (according to levels)

Piperacillin-tazobactam 4.5 g tds

Meropenem 500 mg to 1 g tds

Ticarcillin/clavulanate 3.2 g tds

Pseudomonas

Ciprofloxacin 500 mg bd

Ceftazidime 1-2 gtds

Gentamicin 5 mg/kg/day (according to levels) Piperacillin-tazobactam 4.5 g tds Meropenem 500 mg to 1 g tds Ticarcillin/clavulanate 3.2 g tds

Intramuscular antibiotics.

Ceftriaxone 1 g daily IM to treat Gram-positives and Gram-negatives.

Teicoplanin 400 mg daily IM to treat Gram-positives including MRSA.

Teicoplanin initially should be given as 400 mg 12 hourly for 3 doses, as a loading regimen.

Imipenem w. cilastatin 500 mg bd IM to treat Gram-positives, Gram-negatives and anaerobes.

First dose of doxycycline should be 200 mg.

bd, twice daily; tds, three times daily; qds, four times daily.

Oral agents are ciprofloxacin and trimethoprim. Parenteral agents include ceftazidime, aminoglycosides, meropenem and piperacillin/tazobactam, and ticarcillin/ clavulanate.

Pseudomonas

Pseudomonas can be responsible for definite tissue damage.

It may be sensitive to ciprofloxacin as an oral agent. Otherwise parenteral therapy is necessary and includes ceftazidime, aminoglycosides, meropenem, piperacillin/ tazobactam, and ticarcillin/clavulanate.

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