Preliminary findings from the largestever study of treatments for diabetes provide no evidence that intensive treatment

Interim results from the ADVANCE Study, involving 11,140 high-risk patients with type 2 diabetes, provide no evidence of an increased risk of death among those patients receiving intensive treatment to lower blood glucose (sugar). These findings contrast with those reported last week by the US National Heart Lung and Blood Institute suggesting that intensive glucose lowering treatment levels had increased the death rate among patients with diabetes recruited to the ACCORD trial. ADVANCE was...

When Sugar Management Goes Awry

Digestible carbohydrates are broken down in the intestine into their simplest form, sugar, which then enters the blood. As blood sugar levels rise, special cells in the pancreas churn out more and more insulin, a hormone that signals cells to absorb blood sugar for energy or storage. As cells sponge up blood sugar, its levels in the bloodstream fall back to a preset minimum. So do insulin levels. In some people, this cycle doesn't work properly. People with type-1-diabetes (once called insulin...

The Diabetes Damage Cascade

Glycation and oxidative stress are central to the damage caused by diabetes. Unfortunately, neither of them figures into conventional treatment for diabetes, which is generally concerned only with blood sugar control. Glycation occurs when glucose reacts with protein, resulting in sugar-damaged proteins called advanced glycation end products (AGEs) (Kohn RR et al 1984 Monnier VM et al 1984). One well-known aGe among diabetics is glycated hemoglobin (HbA1c). HbA1c is created when glucose...

Toma Grubb

Throughout my life, I've been pretty active. Even as a teen, I was involved in sports and activities that can take a toll on the human body. My experience as a DUSTOFF pilot DUSTOFF is the call sign for US Army air ambulance helicopters in the Vietnam War gave me a taste for the rush of adrenaline that later in my life I was able to achieve without the added threat of live ammunition. Well into my fifties, I participated in sports and activities that many abandon earlier in their lives, ranging...