Treatment of CHF in Patients with Diabetes The diagnosis of diabetes in clinical trials of CHF

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Various definitions of diabetes are used in clinical trials of CHF. For example, in ATLAS only those receiving medical therapy for diabetes were considered as having diabetes (Ryden etal., 2000) whereas in SOLVD the diagnosis was based on self-reporting by the patient or documentation in the patient's medical records (Shindler etal., 1996). The unrecognised prevalence of diabetes and impaired glucose tolerance in RESOLVD suggests that it is likely that many patients with unrecognised abnormalities of glucose metabolism are included in the major trials of CHF. The diagnostic criteria for diabetes in clinical practice are described in Chapter 11.

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