All major pathophysiological pathways leading to accelerated atherothrombosis are disturbed in patients with type 2 diabetes. However, to prove that a risk factor is contributing to a higher risk of cardiovascular disease in patients with type 2 diabetes, two conditions must be fulfilled. First, a potential risk factor has to be associated with cardiovascular risk in longitudinal studies. Secondly, evidence from trials is needed to demonstrate that normalisation of a risk factor reduces the cardiovascular event rate. Many potential risk factors from atherothrombosis in patients with type 2 diabetes have been studied in a cross-sectional setting. With respect to endothelial function, previous studies have shown that subjects with insulin resistance or type 2 diabetes have an impairment in their ability to increase blood flow to peripheral insulin-sensitive tissues, at least partly due to their inability to induce NO-mediated vasodilatation (Creager etal., 2003). However, endothelial dysfunction is difficult to measure in large population-based studies, and therefore prospective studies on type 2 diabetic patients are missing.
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.