Mechanistic studies

Results from physiological and experimental studies support an important role of glucose in the development of atherothrombotic disease. Endothelial dysfunction is a feature of T2D (Williams etal., 1996) and hyperglycaemia appears to play a specific role (Hogikyan etal., 1998). Glucose-induced oxidative stress has several implications for acceleration of atherosclerotic plaque formation (Giugliano etal., 1996; Ceriello, 2003) and pro-inflammatory cytokine release has been demonstrated in response to hyperglycaemia (Esposito etal., 2002). In addition, glycosylated products including LDL-cholesterol (Graier and Kostner, 1997)) and advanced glycosylation end-products (Vlassara and Palace, 2002) have been shown to disrupt normal macrovascular function. Therefore, hyperglycaemia undoubtedly plays a role in diabetic vascular disease, and it is likely that it behaves as a continuous risk factor even through the spectrum of 'normoglycaemia'.

0 0

Post a comment