Hospitalisation due to CHF in patients with both diabetes and CHF

Patients with both diabetes and CHF are frequently hospitalised due to CHF. In the BEST trial, diabetes was an independent predictor of hospitalisation due to CHF (relative risk 1.16 (1.02-1.32), P = 0.027) (Domanski etal., 2003). In the RESOLVD study, diabetes was again an independent predictor of CHF hospitalisation (Suskin etal., 2000).

5.7 CHRONIC HEART FAILURE, ABNORMALITIES OF INSULIN AND GLUCOSE METABOLISM 103

In the placebo arm of MERIT-HF, patients with diabetes had a 76% (38-126%, P < 0.0001) greater risk of hospitalisation due to CHF compared to those without diabetes (Deedwania etal., 2005). Patients with diabetes in the placebo group with NYHA III and IV CHF and ejection fraction < 25 had a risk of hospitalisation due to CHF that was almost four times higher than the risk for all placebo-treated patients without diabetes.

Patients with diabetes in the ATLAS CHF trial had more admissions to hospital than patients without diabetes (Ryden etal., 2000). Patients with diabetes had an average of three all-cause hospitalisations with a mean of 21.4 days in hospital compared to 2.2 all-cause hospitalisations with a mean of 17.7 days in hospital for patients without diabetes.

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