Metabolic Consequences Of Obesity Why Does It Predispose To

Much work has been done in recent years to understand the links between physical inactivity, obesity, and the development of T2DM. Still no clear, unifying hypothesis has been able to encompass the complex web of metabolic and molecular defects that accompany T2DM. However, much has been learned on how dysfunctional adipose tissue in obesity impairs glucose homeostasis in humans, which can be separated conceptually in two major mechanisms: (a) dysfunctional fat viewed as an "endocrine organ," actively involved in releasing a number of cytokines that promote systemic inflammation that cause/promote muscle/liver insulin resistance, and (b) abnormal dysfunctional fat causing "lipo-toxicity," where sick insulin-resistant adipocytes cause ectopic fat deposition in skeletal muscle, liver, and pancreatic P-cells, with devastating effects for glucose homeostasis.

Keep Your Weight In Check During The Holidays

Keep Your Weight In Check During The Holidays

A time for giving and receiving, getting closer with the ones we love and marking the end of another year and all the eating also. We eat because the food is yummy and plentiful but we don't usually count calories at this time of year. This book will help you do just this.

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